The “Individual Risk Profile DRIVE and Endothelial TARGET in Clinical Management of Vascular Patients” Symposium held at ESVS 35th Annual Meeting in Rotterdam 2021, is introduced by Prof. Mauro Gargiulo and co-chaired by Stavros Kakkos. Very interesting challenges in the clinical management of vascular patients with peripheral artery disease presented by top international KOLs Arkadiusz Jawien, Ferdinando Mannello, and Armando Mansilha, and the following insightful faculty discussion about new options are now freely available on WIN – Vascular Insight Nautilus!